On a mission

to cure neurodegenerative disease

and delay brain aging

Approach

Unlocking nature’s blueprint for resilience

Our platform identifies naturally occuring gene variants that protect against neurodegeneration. Using machine learning to mine large-scale genomic and clinical datasets, we identify and prioritize gene variants with the strongest protective effects and rapidly design oligonucleotide therapeutics mimicking their effect.

De-risked by human genetics

By mimicking protective mechanisms found in resilient individuals, we target genetically validated pathways already shown to slow or prevent disease in the human population. This reduces reliance on hypothetical biologic mechanisms, validation bias from cell and animal disease models, and ultimately minimizes translational risk.

Broad impact beyond rare mutations

Unlike therapies aimed only at rare genetic subtypes, we address shared drivers of both familial and sporadic forms of ALS, FTD, and other neurodegenerative diseases, often related to neuroinflammation. This strategy dramatically expands both the patient population and commercial potential.